Amoxicillin Clavulanate Potassium Granules Instructions

Veterinary

【Veterinary drug name】

Generic Name: Amoxicillin and Clavulanate Potassium Granules

Product Name: Liankla

English name:Amoxicillin and Clavulanate Potassium Granules

Chinese Pinyin:Amoxicillin Kelaweisuanjia Keli

【Main Ingredients】Amoxicillin、Potassium clavulanate。

【Properties】This product is whitetoLight yellow granules。

【Pharmacological action】Pharmacodynamics   This product is a compoundb-Lactam antibiotics, due tob-The activity of amoxicillin as a beta-lactamase inhibitor makes itb-Lactamase-sensitive strains.

Amoxicillin is an antibiotic that kills bacteria by inhibiting the synthesis of bacterial cell walls and preventing bacterial reproduction. It can inhibit the formation of linear polymers of peptidoglycan chains in the cell walls of Gram-positive bacteria, and is also sensitive to Gram-negative bacteria whose cell walls are partially composed of outer proteins and lipopolysaccharides.b-The most important mechanism of beta-lactam antibiotics is that penicillins are produced by certain bacteria.b-Lactamase is inactivated by hydrolysis, while clavulanic acid is ab-Lactamase inhibitors, which preventb-Lactamaseb-The destruction of the lactam ring. The reaction between the enzyme and clavulanic acid is irreversible, thus retaining the antibacterial activity of penicillins.

The susceptibility and resistance of strains vary by geographic region and can also change over time.

The determined minimum inhibitory concentrations of amoxicillin-clavulanic acid combination preparations for different bacterial strains (in terms of amoxicillin) are as follows:

    Pharmacokinetics   Pig1kgTake this product (amoxicillin) orally10mgand clavulanic acid2.5mg) After that, amoxicillin1.47The peak blood concentration is reached after 12 hours.C_maxfor1.44mg/L, blood elimination half-lifet_1/2for1.56Hour,MRT_lastfor2.9hours, the bioavailability is28.75%; Clavulanic acid approx.0.72The peak blood concentration is reached after 12 hours.C_maxfor2.34mg/L, blood elimination half-lifet_1/2for1.74Hour, MRT_lastfor2.09hours, the bioavailability is61.50%。

【Indications】 For the treatment of pigs infected with Haemophilus parasuis and Actinobacillus pleuropneumoniaerespiratory tractInfect。

【Usage and Dosage】 Press this productMixed Drinks:Every1kgbody weight,pig50mg,Everyday2times, used continuously5day。

【Adverse Reactions】 1.Mild gastrointestinalSymptoms(diarrhea and vomiting)。

2.Allergic reaction may occur。

【Notes】1.It should not be used in pigs allergic to penicillin or cephalosporin antibiotics.

2.According to the recommended usage, the drug solution is prepared24Stable within hours.

3.During the treatment period, the drug solution should be the only source of drinking water. Drinking water can be supplied only after all the drug solution has been consumed. The concentration of the drug solution can be adjusted according to the health status of the animal. It is recommended to use this product according to1.5～7.5g/LThe concentration is dissolved in about20Use in water at ℃.

4.Keep container tightly closed to protect from moisture.

5.This product cannot be used simultaneously with acidifiers.

6.The animal's ability to take medication may be altered by the disease. Injections should be used when the animal is unable to drink or eat.

【Withdrawal period】pig1day

【Specification】100g: C₁₆H₁₉N₃THE₅S 20gandC₈H₉NO₅ 5g

【Package】

【Storage】Sealed, store in a cool, dark, dry place.

[Validity period]24Months.

【Approval number】Veterinary drug050307143

【Production Date】

【Product batch number】

【Valid until】

【Manufacturer】Inner Mongolia Federal Animal Health Pharmaceutical Co., Ltd.